1.
Pakistan Journal of Biochemistry. 1994; 27 (1-2): 81-85
in English
| IMEMR
| ID: emr-35112
ABSTRACT
Single administration of sodium salicylate at doses of 400 mg/kg increased hepatic holo-tryptophan pyrrolase activity but did not produce any effect an apotryptophan pyrrolase activity in rats. Repeated administration of the drug at doses of 100 mg/kg did not alter holo-enzyme activity but decreased apo and total enzyme activity in rats killed 24 hours later. Administration of 400 mg/kg sodium salicylate to 5 day, 100 mg/kg sodium salicylate injected rats did not increase holo or apo-tryptophan pyrrolase activity. Possible role of tryptophan pyrrolase in the sodium- salicylate induced changes of brain serotonin metabolism is discussed
Subject(s)
Animals, Laboratory , Tryptophan Oxygenase/drug effects , Rats , Tryptophan Oxygenase/biosynthesis , Liver/enzymology , Sodium Salicylate/pharmacokinetics
2.
Indian J Exp Biol
;
1977 Feb; 15(2): 98-104
Article
in English
| IMSEAR
| ID: sea-60812
3.
Indian J Biochem Biophys
;
1973 Sep; 10(3): 191-4
Article
in English
| IMSEAR
| ID: sea-28546